Human B-cell Linker Protein, BLNK ELI

Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development.

Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK.

Modulates AP1 activation.

Important for the activation of NF-kappa-B and NFAT.

Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes.

However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling.

May be required for the RAC1-JNK pathway.

Plays a critical role in orchestrating the pro-B cell to pre-B cell transition.

May play an important role in BCR-induced B-cell apoptosis.