Human Bcl2;adenovirus E1B 19 kDa protein-interacting protein 3,BNIP3 ELI
3,140.00 ₪
Apoptosis-inducing protein that can overcome BCL2 suppression.
May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2.
Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria.
The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.
Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
{ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}.
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