Human BCL2;Adenovirus E1B 19 kDa Protein-Interacting Protein 3-Like,BNIP3L ELI
3,140.00 ₪
Induces apoptosis.
Interacts with viral and cellular anti-apoptosis proteins.
Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis.
Inhibits apoptosis induced by BNIP3.
Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria.
The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.
May function as a tumor suppressor.
{ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.
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