Human Beta-1, 3-N-acetylglucosaminyltransferase Radical Fringe, RFNG ELI

Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules.

Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1.

May be involved in limb formation and in neurogenesis.