Human Beta-site APP-cleaving Enzyme 2,BACE2 ELI

Responsible for the proteolytic processing of the amyloid precursor protein (APP).

Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

It has also been shown that it can cleave APP between residues 671 and 672.

Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142).

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