Human Bone Morphogenetic Protein Receptor 2, BMPR2 ELI

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.

Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Binds to BMP7, BMP2 and, less efficiently, BMP4.

Binding is weak but enhanced by the presence of type I receptors for BMPs.

Mediates induction of adipogenesis by GDF6.