Human Brca1-associated Protein, BRAP ELI

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein.

Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation.

May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.