Human C-C Chemokine Receptor Type 4, CCR4 ELI

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1.

The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system.

Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates.

In the CNS, could mediate hippocampal-neuron survival.