Human C-C Motif Chemokine 25, CCL25 ELI

Potentially involved in T-cell development.

Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils.

Binds to CCR9.

Isoform 2 is an antagonist of isoform 1.

Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.