Human C-C Motif Chemokine 5, CCL5/RANTES ELI
3,140.00 ₪
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils.
Causes the release of histamine from basophils and activates eosinophils.
May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5.
One of the major HIV-suppressive factors produced by CD8+ T-cells.
Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection.
The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed: 16791620, PubMed: 1380064, PubMed: 8525373, PubMed: 9516414, PubMed: 15923218).
May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation.
Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases.
By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed: 23979485).
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