Human Calcitonin Like Receptor, CLR ELI

This is a receptor for calcitonin.

The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

[Isoform 2]: Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase (PubMed: 7476993).

Does not undergo receptor internalization following ligand binding (PubMed: 7476993).