Human Calnexin, CNX ELI

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum.

It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits.

It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.

Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation.

Additionally it may play a role in receptor-mediated endocytosis at the synapse.