Human Calpain-5, CAPN5 ELI

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene.

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes.

A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits.

CAPN5 is one of the large subunits.

Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV.

Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.