Human Calreticulin 3, CALR3 ELI

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle.

This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed: 7876246).

Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed: 11149926).

Involved in maternal gene expression regulation.

May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).

Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity).