Human Carbohydrate Sulfotransferase 5, CHST5 ELI

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors.

Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates.

However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures.

Has no activity toward keratan.

Not involved in generating HEV-expressed ligands for SELL.

Its substrate specificity may be influenced by its subcellular location.