Human Caspase 14, CASP14 ELI
3,140.00 ₪
Non-apoptotic caspase involved in epidermal differentiation.
Is the predominant caspase in epidermal stratum corneum (PubMed: 15556625).
Seems to play a role in keratinocyte differentiation and is required for cornification.
Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity).
In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed: 16854378, PubMed: 19960512).
Involved in processing of prosaposin in the epidermis (By similarity).
May be involved in retinal pigment epithelium cell barrier function (PubMed: 25121097).
Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed: 24743736).
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