Human Caspase 3, CASP3 ELI

Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed: 7596430).

At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond (PubMed: 7774019).

Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain.

Cleaves and activates caspase-6, -7 and -9 (PubMed: 7596430).

Involved in the cleavage of huntingtin (PubMed: 8696339).

Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed: 21357690).

Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed: 23152800).