Human Caspase-9,CASP9 ELI

Involved in the activation cascade of caspases responsible for apoptosis execution.

Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3.

Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner.

Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).; Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.