Human Caveolin-1, CAV-1 ELI

May act as a scaffolding protein within caveolar membranes (PubMed: 11751885).

Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation.

Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed: 19262564).

Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.

Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed: 17287217).

Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity).

Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed: 25893292).