Human Cc-Chemokine Receptor 5, CCR-5 ELI

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.

May play a role in the control of granulocytic lineage proliferation or differentiation.

Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed: 30713770).

(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.