Human CCN family member 1,CCN1 ELI

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion.

Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5.

CCN1-mediated gene regulation is dependent on heparin-binding.

Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1.

Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

{ECO:0000269|PubMed:11584015}.