Human CCR4-NOT transcription complex subunit 7,CNOT7 ELI
3,140.00 ₪
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate.
Its function seems to be partially redundant with that of CNOT8.
Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation.
Additional complex functions may be a consequence of its influence on mRNA expression.
Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
{ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:20634287, ECO:0000269|PubMed:23236473}.
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