Human Cd226 Antigen, CD226 ELI

Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed: 8673704).

Cell surface receptor for NECTIN2.

Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG.

Competes with PVRIG for NECTIN2-binding (PubMed: 26755705).