Human Cellular Communication Network Faxtor 3,CCN3 ELI

Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162).

Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078).

Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287).

Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162).

Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355).

Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis.

In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522).

Plays also a role in cutaneous wound healing acting as integrin receptor ligand.

Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5.

Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078).

Involved in bone regeneration as a negative regulator (By similarity).

Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891).

Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity).

Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504).

Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity).

Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression.

Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891).

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