Human Cgmp-dependent Protein Kinase 2, PRKG2 ELI
3,140.00 ₪
Crucial regulator of intestinal secretion and bone growth (By similarity).
Phosphorylates and activates CFTR on the plasma membrane.
Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity).
Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity.
Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity).
Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts.
Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).
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