Human Chemokine (C-C motif) ligand 4,CCL4 ELI

Monokine with inflammatory and chemokinetic properties.

Binds to CCR5.

One of the major HIV-suppressive factors produced by CD8+ T-cells.

Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).

The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells.

MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.

{ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}.