Human Chloride Channel Accessory 1, CLCA1 ELI

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.

This gene encodes a member of the calcium sensitive chloride conductance protein family.

To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions.

The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined.

The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.

Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.