Human Chloride Intracellular Channel Protein 4, CLIC4 ELI

Can insert into membranes and form poorly selective ion Channels that may also transport chloride ions.

Channel activity depends on the pH.

Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions.

Promotes cell-surface expression of HRH3.

Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis.

Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).