Human Chromatin Assembly Factor 1 Subunit B, CHAF1B ELI

Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair.

Assembles histone octamers onto replicating DNA in vitro.

CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.