Human Chromobox Protein Homolog 3, CBX3 ELI

Seems to be involved in transcriptional silencing in heterochromatin-like complexes.

Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.

May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR).

Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).