Human Class E Basic Helix-Loop-Helix Protein 41, BHLHE41 ELI

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed: 11278948, PubMed: 14672706, PubMed: 15193144, PubMed: 15560782, PubMed: 18411297, PubMed: 19786558, PubMed: 25083013).

Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop).

Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2.

Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed: 25083013).

Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2.

Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11 (By similarity).