Human Cluster of differentiation 160,CD160 ELI

[CD160 antigen]: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation.

Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:19109136, PubMed:11978774, PubMed:17307798).

Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372, PubMed:12486241).

In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241).

On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372).

Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144).

On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620).

Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes.

Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity).

On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050).

In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).

{ECO:0000250|UniProtKB:O88875, ECO:0000269|PubMed:11978774, ECO:0000269|PubMed:12486241, ECO:0000269|PubMed:16809620, ECO:0000269|PubMed:17307798, ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:19109136, ECO:0000269|PubMed:25255144, ECO:0000269|PubMed:9973372}.; [CD160 antigen, soluble form]: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.

{ECO:0000269|PubMed:17237375}.