Human Cluster of differentiation 28,CD28 ELI

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933).

Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).

{ECO:0000269|PubMed:15067037, ECO:0000269|PubMed:8617933}.