Human Cluster of Differentiation 3, CD3 ELI

Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination.

The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.

The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.

Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation.

May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.