Human cluster of differentiation 45,CD45 ELI

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor.

Acts as a positive regulator of T-cell coactivation upon binding to DPP4.

The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN.

Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

{ECO:0000250, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:2845400}.; (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.

{ECO:0000269|PubMed:22174689}.