Human Cofilin-1, CFL1 ELI

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed: 11812157).

In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed: 15580268).

Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity).

Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed: 2183$498.00|$360.007).

Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed: 23633677).

Required for neural tube morphogenesis and neural crest cell migration (By similarity).