Human Coiled-Coil Domain-containing Protein 134, CCDC134 ELI
3,140.00 ₪
In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed: 25125657).
Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed: 25125657).
May inhibit ERK and JNK signaling activity (PubMed: 18087676, PubMed: 23070808).
May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed: 23070808).
In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity.
May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity.
May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
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