Human Collagen alpha-1(XVIII) chain,COL18A1 ELI

Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.

{ECO:0000269|PubMed:10942434}.; [Non-collagenous domain 1]: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling.

{ECO:0000269|PubMed:11257123}.; [Endostatin]: Potently inhibits endothelial cell proliferation and angiogenesis (PubMed:9459295).

May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity).

Inhibits VEGFA-induced endothelial cell proliferation and migration.

Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2.

Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity).

May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123).

{ECO:0000250|UniProtKB:P39061, ECO:0000269|PubMed:11257123, ECO:0000269|PubMed:9459295}.