Human Collectin-12, COLEC12 ELI

Scavenger receptor that displays several functions associated with host defense.

Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast.

Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells.

Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells.

Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR).

May also play a role in the clearance of amyloid-beta in Alzheimer disease.