Human Colorectal mutant cancer protein,MCC ELI
3,140.00 ₪
Candidate for the putative colorectal tumor suppressor gene located at 5q21.
Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells.
Inhibits DNA binding of b-catenin/TCF/LEF transcription factors.
Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440).
Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).
{ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}.
Quantity