Human Complement decay-accelerating factor,DAF ELI

This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation.

Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274).

Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829).

{ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5.

{ECO:0000269|PubMed:9151867}.; (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable).

{ECO:0000269|PubMed:8764022}.; (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21.

{ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}.