Human Complement Factor H, CFH ELI

Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation.

Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces (PubMed: 21285368, PubMed: 25402769).

Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop (PubMed: 19503104).

As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b (PubMed: 18252712, PubMed: 28671664).

In addition, mediates several cellular responses through interaction with specific receptors.

For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens.

In turn, these pathogens are phagocytosed and destroyed (PubMed: 9558116, PubMed: 20008295).