Human Complement Receptor 1;Erythrocyte,CR1 ELI
3,140.00 ₪
Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069).
Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069).
Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757).
Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728).
{ECO:0000269|PubMed:25742728, ECO:0000269|PubMed:2963069, ECO:0000269|PubMed:2972794, ECO:0000269|PubMed:8175757}.; (Microbial infection) Acts as a receptor for Epstein-Barr virus.
{ECO:0000269|PubMed:23416052}.
Quantity