Human Crk-like Protein, CRKL ELI

Crk-like protein is a protein that in humans is encoded by the CRKL gene.

v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains.

CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion.

It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL.

In addition, CRKL has oncogenic potential.