Human Cubilin, CUBN ELI

Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PubMed: 9572993, PubMed: 10371504, PubMed: 11717447, PubMed: 11606717, PubMed: 14576052).

Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1.

Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex (PubMed: 9572993, PubMed: 14576052).

Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex.

Ligand binding requires calcium (PubMed: 9572993).

Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac.

May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol.

Binds to LGALS3 at the maternal-fetal interface.