Human CXC-chemokine receptor 1,CXCR1 ELI

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor.

Binding of IL-8 to the receptor causes activation of neutrophils.

This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system.

This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.