Human CXC-chemokine receptor 2,CXCR2 ELI

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor.

Binding of IL-8 to the receptor causes activation of neutrophils.

This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Binds to IL-8 with high affinity.

Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.