Human Cyclic Amp-dependent Transcription Factor, ATF-3 ELI

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters.

Represses transcription from promoters with ATF sites.

It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter.

[Isoform 2]: Activates transcription presumably by sequestering inhibitory cofactors away from the promoters.