Human Cytochrome B-245 Heavy Chian, CYBB ELI

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide.

It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior.

Also functions as a voltage-gated proton Channel that mediates the H(+) currents of resting phagocytes.

It participates in the regulation of cellular pH and is blocked by zinc.