Human Cytochrome P450 1A1, CYP1A1 ELI
3,140.00 ₪
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed: 11555828, PubMed: 14559847, PubMed: 12865317, PubMed: 15805301, PubMed: 15041462, PubMed: 18577768, PubMed: 19965576, PubMed: 20972997, PubMed: 10681376).
Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed: 11555828, PubMed: 14559847, PubMed: 12865317, PubMed: 15805301, PubMed: 15041462, PubMed: 18577768, PubMed: 19965576, PubMed: 20972997, PubMed: 10681376).
Catalyzes the hydroxylation of carbon-hydrogen bonds.
Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed: 11555828, PubMed: 14559847, PubMed: 12865317, PubMed: 15805301).
Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed: 15041462, PubMed: 18577768).
Catalyzes the epoxidation of double bonds of certain PUFA (PubMed: 15041462, PubMed: 19965576, PubMed: 20972997).
Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed: 20972997).
Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed: 15041462).
May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues.
Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed: 10681376).
May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed: 21068195).
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